How Crystallographic Orientation-Induced Fibrinogen Conformation Affects Platelet Adhesion and Activation on TiO₂.

ABSTRACT: Control of protein adsorption is essential for successful integration of healthcare materials into the body. Human plasma fibrinogen (HPF), especially its conformation is a key upstream regulator for platelet behavior and thus pathological clot formation at the blood-biomaterial interface. A previous study by the authors revealed that the conformation of adsorbed HPF can be controlled by rutile surface crystallographic orientation. Therefore, it is hypothesized that pre-adsorbed HPF on specific rutile orientation can regulate platelets adhesion and activation. Here, it is shown that platelets exposed to the four low index (110), (100), (101), (001) facets of TiO₂ (rutile) exhibit surface-specific behavior. Scanning electron microscopy (SEM) observations of platelets morphology a

SUBMITTER: Struczynska M 

PROVIDER: S-EPMC11469089 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature