Pump-Less Platform Enables Long-Term Recirculating Perfusion of 3D Printed Tubular Tissues.

ABSTRACT: The direction and pattern of fluid flow affect vascular structure and function, in which vessel-lining endothelial cells exhibit variable cellular morphologies and vessel remodeling by mechanosensing. To recapitulate this microenvironment, some approaches have been reported to successfully apply unidirectional flow on endothelial cells in organ-on-a-chip systems. However, these platforms encounter drawbacks such as the dependency on pumps or confinement to closed microfluidic channels. These constraints impede their synergy with advanced biofabrication techniques like 3D bioprinting, thereby curtailing the potential to introduce greater complexity into engineered tissues. Herein, a pumpless recirculating platform (UniPlate) that enables unidirectional media recirculation through 3D printed

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11469154 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature