Engineering Lipid Spherulites for the Sustained Release of Highly Dosed Small Hydrophilic Compounds.

ABSTRACT: Currently, there is a lack of parenteral sustained release formulations for the delivery of highly dosed small hydrophilic drugs. Therefore, parenteral lipid spherulites are engineered capable of entrapping large amounts of such compounds and spontaneously releasing them in a sustained fashion. A library of spherulites is prepared with a simple green process, using phosphatidylcholine (PC) and/or phosphatidylethanolamine (PE), nonionic surfactants and water. The vesicle formulations exhibiting appropriate size distribution and morphology are selected and loaded with 4,6-di-O-(methoxy-diethyleneglycol)-myo-inositol-1,2,3,5-tetrakis(phosphate), ((OEG₂ )₂ -IP4), an inositol phosphate derivative currently under clinical evaluation for the treatment of aortic valve stenosi

SUBMITTER: Montanari E 

PROVIDER: S-EPMC11469156 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature