Microarchitected Compliant Scaffolds of Pyrolytic Carbon for 3D Muscle Cell Growth.

ABSTRACT: The integration of additive manufacturing technologies with the pyrolysis of polymeric precursors enables the design-controlled fabrication of architected 3D pyrolytic carbon (PyC) structures with complex architectural details. Despite great promise, their use in cellular interaction remains unexplored. This study pioneers the utilization of microarchitected 3D PyC structures as biocompatible scaffolds for the colonization of muscle cells in a 3D environment. PyC scaffolds are fabricated using micro-stereolithography, followed by pyrolysis. Furthermore, an innovative design strategy using revolute joints is employed to obtain novel, compliant structures of architected PyC. The pyrolysis process results in a pyrolysis temperature- and design-geometry-dependent shrinkage of up to 73%, enabli

SUBMITTER: Taale M 

PROVIDER: S-EPMC11469158 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature