Mimicking the Human Tympanic Membrane: The Significance of Scaffold Geometry.

ABSTRACT: The human tympanic membrane (TM) captures sound waves from the environment and transforms them into mechanical motion. The successful transmission of these acoustic vibrations is attributed to the unique architecture of the TM. However, a limited knowledge is available on the contribution of its discrete anatomical features, which is important for fabricating functional TM replacements. This work synergizes theoretical and experimental approaches toward understanding the significance of geometry in tissue-engineered TM scaffolds. Three test designs along with a plain control are chosen to decouple some of the dominant structural elements, such as the radial and circumferential alignment of the collagen fibrils. In silico models suggest a geometrical dependency of their mechanical and acous

SUBMITTER: Anand S 

PROVIDER: S-EPMC11469228 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature