A Novel Computational Biomechanics Framework to Model Vascular Mechanopropagation in Deep Bone Marrow.

ABSTRACT: The mechanical stimuli generated by body exercise can be transmitted from cortical bone into the deep bone marrow (mechanopropagation). Excitingly, a mechanosensitive perivascular stem cell niche is recently identified within the bone marrow for osteogenesis and lymphopoiesis. Although it is long known that they are maintained by exercise-induced mechanical stimulation, the mechanopropagation from compact bone to deep bone marrow vasculature remains elusive of this fundamental mechanobiology field. No experimental system is available yet to directly understand such exercise-induced mechanopropagation at the bone-vessel interface. To this end, taking advantage of the revolutionary in vivo 3D deep bone imaging, an integrated computational biomechanics framework to quantitatively evaluate the

SUBMITTER: Zhao YC 

PROVIDER: S-EPMC11469229 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature