T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier.

ABSTRACT: Delivery of therapeutics to the central nervous system (CNS) is challenging due to the presence of the blood-brain barrier (BBB). Amongst various approaches that have been explored to facilitate drug delivery to the CNS, the use of cells that have the intrinsic ability to cross the BBB is relatively unexplored, yet very attractive. This paper presents a first proof-of-concept that demonstrates the feasibility of activated effector/memory CD4⁺ helper T cells (CD4⁺ T_EM cells) as carriers for the delivery of polymer nanoparticles across the BBB. This study shows that CD4⁺ T_EM cells can be decorated with poly(ethylene glycol)-modified polystyrene nanoparticles using thiol-maleimide coupling chemistry, resulting in the immobilization of ≈10

SUBMITTER: Ayer M 

PROVIDER: S-EPMC11469241 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature