An Injectable Meta-Biomaterial: From Design and Simulation to In Vivo Shaping and Tissue Induction.

ABSTRACT: A novel type of injectable biomaterial with an elastic softening transition is described. The material enables in vivo shaping, followed by induction of 3D stable vascularized tissue. The synthesis of the injectable meta-biomaterial is instructed by extensive numerical simulation as a suspension of irregularly fragmented, highly porous sponge-like microgels. The irregular particle shape dramatically enhances yield strain for in vivo stability against deformation. Porosity of the particles, along with friction between internal surfaces, provides the elastic softening transition. This emergent metamaterial property enables the material to reversibly change stiffness during deformation, allowing native tissue properties to be matched over a wide range of deformation amplitudes. After subcutan

SUBMITTER: Beduer A 

PROVIDER: S-EPMC11469256 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature