Tougher Bioadhesives through Dual Stimulation Strategies.

ABSTRACT: Carbene-based bioadhesives have favourable attributes for tissue adhesion, including non-specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene-precursor (diazirine) also creates inert side products that are absent under thermal activation. Herein, a dual activation method combines light irradiation at elevated temperatures for the evaluation of diazirine depletion and effects on cohesive properties. A customized photo/thermal-rheometer evaluates viscoelastic properties, correlated to the kinetics of carbene:diazoalkane ratios via ¹⁹F NMR). The latter exploits the sensitive -CF₃ functional group to determine joule-based light/temperature kinetics on trifluoroaryl diazirine consumption.

SUBMITTER: Ang EWJ 

PROVIDER: S-EPMC11469300 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature