Plasma proteomics reveals the potential causal impact of extracellular matrix proteins on abdominal aortic aneurysm.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a common and life-threatening vascular disease. Genetic studies have identified numerous associated loci, many potentially encoding plasma proteins. However, the causal effects of plasma proteins on AAA have not been thoroughly studied. We used genetic causal inference approaches to identify plasma proteins that have a potential causal impact on AAA.

Methods

Causal inference was performed using two-sample Mendelian randomization (MR). For AAA, we utilized recently published summary statistics from a multi-population genome-wide association (GWAS) meta-analysis including 39,221 individuals with, and 1,086,107 individuals without AAA from 14 cohorts. We used protein quantitative trait loci (pQTLs) identified in two large-scale plas

SUBMITTER: Khodursky S 

PROVIDER: S-EPMC11469359 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature