Alcohol, smoking, and brain structure: common or substance specific associations.

ABSTRACT: Alcohol use and smoking are common substance-use behaviors with well-established negative health effects, including decreased brain health. We examined whether alcohol use and smoking were associated with the same neuroimaging-derived brain measures. We further explored whether the effects of alcohol use and smoking on the brain were additive or interactive. We leveraged a cohort of 36,309 participants with neuroimaging data from the UK Biobank. We used linear regression to determine the association between 354 neuroimaging-derived brain measures and alcohol use defined as drinks per week, pack years of smoking, and drinks per week × pack years smoking interaction. To assess whether the brain associations with alcohol are broadly similar or different from the associations with smoking, we

SUBMITTER: Thornton V 

PROVIDER: S-EPMC11469368 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature