Ancestry and somatic profile predict acral melanoma origin and prognosis.

ABSTRACT: Acral melanoma, which is not ultraviolet (UV)-associated, is the most common type of melanoma in several low- and middle-income countries including Mexico. Latin American samples are significantly underrepresented in global cancer genomics studies, which directly affects patients in these regions as it is known that cancer risk and incidence may be influenced by ancestry and environmental exposures. To address this, we characterise the genome and transcriptome of 123 acral melanoma tumours from 92 Mexican patients, a population notable because of its genetic admixture. Compared with other studies of melanoma, we found fewer frequent mutations in classical driver genes such as BRAF, NRAS or NF1. While most patients had predominantly Amerindian genetic ancestry, those wi

SUBMITTER: Basurto-Lozada P 

PROVIDER: S-EPMC11469390 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature