Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence.

ABSTRACT:

Importance

Functional brain networks are associated with both behavior and genetic factors. To uncover biological mechanisms of psychopathology, it is critical to define how the spatial organization of these networks relates to genetic risk during development.

Objective

To determine the relationships among transdiagnostic polygenic risk scores (PRSs), personalized functional brain networks (PFNs), and overall psychopathology (p-factor) during early adolescence.

Design

The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing longitudinal cohort study of 21 collection sites across the United States. Here, we conduct a cross-sectional analysis of ABCD baseline data, collected 2017-2018.

Setting

The ABCD Study^® is a multi-site community-base

SUBMITTER: Sun KY 

PROVIDER: S-EPMC11469391 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature