Leveraging the Genetics of Psychiatric Disorders to Prioritize Potential Drug Targets and Compounds.

ABSTRACT:

Background

Genetics has the potential to inform biologically relevant drug treatment and repurposing which may ultimately improve patient care. In this study, we combine methods which leverage the genetics of psychiatric disorders to prioritize potential drug targets and compounds.

Methods

We used the largest available genome-wide association studies, in European ancestry, of four psychiatric disorders [i.e., attention deficit hyperactivity disorder (ADHD), bipolar disorder, depression, and schizophrenia] along with genes encoding drug targets. With this data, we conducted drug enrichment analyses incorporating the novel and biologically specific GSA-MiXeR tool. We then conducted a series of molecular trait analyses using large-scale transcriptomic and proteomic datasets sam

SUBMITTER: Parker N 

PROVIDER: S-EPMC11469398 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature