Histone-like transcription factor Hfl1p in <i>Candida albicans</i> harmonizes nuclear and mitochondrial genomic network in regulation of energy metabolism and filamentation development.

ABSTRACT: Candida albicans is an opportunistic fungal pathogen known for surviving in various nutrient-limited conditions within the host and causing infections. Our prior research revealed that Hfl1p, an archaeal histone-like or Hap5-like protein, is linked to mitochondrial ATP generation and yeast-hyphae morphogenesis. However, the specific roles of Hfl1p in these virulence behaviours, through its function in the CBF/NF-Y complex or as a DNA polymerase II subunit, remain unclear. This study explores Hfl1p's diverse functions in energy metabolism and morphogenesis. By combining proteomic analysis and phenotypic evaluations of the hfl1Δ/hfl1Δ mutant with ChIP data, we found that Hfl1p significantly impacts mitochondrial DNA-encoded CI subunits, the tricarboxylic acid (TCA) cycle, and m

SUBMITTER: She X 

PROVIDER: S-EPMC11469427 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature