An integrative analysis based on multiple cell death patterns identifies an immunosuppressive subtype and establishes a prognostic signature in lower-grade glioma.

ABSTRACT:

Background

Cell death modulates the biological behaviors of tumors. However, the comprehensive role of the multiple forms of cell death in lower-grade glioma (LGG) is unknown.

Methods

We collected the transcriptional data of LGG patients from public repositories to comprehensively examine six cell death patterns (autophagy, apoptosis, cuproptosis, necroptosis, ferroptosis, and pyroptosis) in LGG samples and systematically correlated these patterns with patient survival, underlying biological processes, and drug sensitivity using serial bioinformatics analysis, clinical sample validation and in vitro assays.

Results

We identified and independently validated three reproducible cell death-based clusters associated with distinct clinical outcomes and tumor microenv

SUBMITTER: Lian H 

PROVIDER: S-EPMC11469432 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature