Investigation of gut microbiota disorders in norovirus infected children patients based on 16s rRNA sequencing.

ABSTRACT:

Background

Norovirus is the leading cause of sporadic viral gastroenteritis cases and outbreaks. Gut microbiota plays a key role in maintaining immune homeostasis. We aimed to investigate the composition and functional effects of gut microbiota in children infected with norovirus.

Methods

Stool samples were collected from 31 children infected with norovirus and 25 healthy children. The gut microbiota was analyzed by 16S rRNA gene sequencing, followed by composition, correlation network, functional and phenotype prediction analyses.

Results

Gut microbiota in children infected with norovirus was characterized by lower species richness and diversity. Veillonella is the dominant gut microbiota specie in norovirus infection. Blautia was significantly lower in

SUBMITTER: Li J 

PROVIDER: S-EPMC11469441 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature