Corticostriatal causality analysis in children and adolescents with attention-deficit/hyperactivity disorder.

ABSTRACT:

Aim

The effective connectivity between the striatum and cerebral cortex has not been fully investigated in attention-deficit/hyperactivity disorder (ADHD). Our objective was to explore the interaction effects between diagnosis and age on disrupted corticostriatal effective connectivity and to represent the modulation function of altered connectivity pathways in children and adolescents with ADHD.

Methods

We performed Granger causality analysis on 300 participants from a publicly available Attention-Deficit/Hyperactivity Disorder-200 dataset. By computing the correlation coefficients between causal connections between striatal subregions and other cortical regions, we estimated the striatal inflow and outflow connection to represent intermodulation mechanisms in corticostriat

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11469573 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature