A multiscale inflammatory map: linking individual stress to societal dysfunction.

ABSTRACT: As populations worldwide show increasing levels of stress, understanding emerging links among stress, inflammation, cognition, and behavior is vital to human and planetary health. We hypothesize that inflammation is a multiscale driver connecting stressors that affect individuals to large-scale societal dysfunction and, ultimately, to planetary-scale environmental impacts. We propose a 'central inflammation map' hypothesis to explain how the brain regulates inflammation and how inflammation impairs cognition, emotion, and action. According to our hypothesis, these interdependent inflammatory and neural processes, and the inter-individual transmission of environmental, infectious, and behavioral stressors - amplified via high-throughput digital global communications - can culminate in a mul

SUBMITTER: Vodovotz Y 

PROVIDER: S-EPMC11469639 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature