Spatial Transcriptomic Signatures of Early Acute T Cell-mediated Rejection in Kidney Transplants.

ABSTRACT:

Background

Kidney transplantation significantly improves the quality of life for those with end-stage renal failure, yet allograft rejection resulting from immune cell interactions remains a persistent challenge. Although T cell-directed immunosuppressive drugs effectively contain graft rejection in most patients, a notable proportion still experiences acute T cell-mediated rejection (TCMR). Despite an emphasis on suppressing T cell-mediated immune responses, successful control over TCMR is not always achieved, suggesting the potential involvement of factors beyond T cells.

Methods

Biopsy samples from suspicious (borderline) for acute TCMR (borderline TCMR) and non-TCMR patients were obtained 9 d postsurgery, and spatial transcriptomics profiling was conducted using the GeoM

SUBMITTER: Kang M 

PROVIDER: S-EPMC11469874 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature