High-resolution ¹H-MRSI at 9.4 T by integrating relaxation enhancement and subspace imaging.

ABSTRACT: Achieving high-resolution and high signal-to-noise ratio (SNR) in vivo metabolic imaging via fast magnetic resonance spectroscopic imaging (MRSI) has been a longstanding challenge. This study combines the methods of relaxation enhancement (RE) and subspace imaging for the first time, enabling high-resolution and high-SNR in vivo MRSI of rodent brains at 9.4 T. Specifically, an RE-based chemical shift imaging sequence, which combines a frequency-selective pulse to excite only the metabolite frequencies with minimum perturbation of the water spins and a pair of adiabatic pulses to spatially localize the slice of interest, is designed and evaluated in vivo. This strategy effectively shortens the apparent T₁ of metabolites, thereby increasing the SNR during relatively short repetiti

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11469943 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature