LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface.

ABSTRACT: Synapses are organized into nanocolumns that control synaptic transmission efficacy through precise alignment of postsynaptic neurotransmitter receptors and presynaptic release sites. Recent evidence show that Leucine-Rich Repeat Transmembrane protein LRRTM2, highly enriched and confined at synapses, interacts with Neurexins through its C-terminal cap, but the role of this binding interface has not been explored in synapse formation and function. Here, we develop a conditional knock-out mouse model (cKO) to address the molecular mechanisms of LRRTM2 regulation, and its role in synapse organization and function. We show that LRRTM2 cKO specifically impairs excitatory synapse formation and function in mice. Surface expression, synaptic clustering, and membrane dynamics of LRRTM2 are tightly

SUBMITTER: Liouta K 

PROVIDER: S-EPMC11470055 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature