Cobalt(III) Halide Metal-Organic Frameworks Drive Catalytic Halogen Exchange.

ABSTRACT: The selective halogenation of complex (hetero)aromatic systems is a critical yet challenging transformation that is relevant to medicinal chemistry, agriculture, and biomedical imaging. However, current methods are limited by toxic reagents, expensive homogeneous second- and third-row transition metal catalysts, or poor substrate tolerance. Herein, we demonstrate that porous metal-organic frameworks (MOFs) containing terminal Co(III) halide sites represent a rare and general class of heterogeneous catalysts for the controlled installation of chlorine and fluorine centers into electron-deficient (hetero)aryl bromides using simple metal halide salts. Mechanistic studies support that these halogen exchange (halex) reactions proceed via redox-neutral nucleophilic aromatic substitution (S_N

SUBMITTER: Azbell TJ 

PROVIDER: S-EPMC11470105 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature