Regional tuning of photoreceptor adaptation in the primate retina.

ABSTRACT: Adaptation in cone photoreceptors allows our visual system to effectively operate over an enormous range of light intensities. However, little is known about the properties of cone adaptation in the specialized region of the primate central retina called the fovea, which is densely packed with cones and mediates high-acuity central vision. Here we show that macaque foveal cones exhibit weaker and slower luminance adaptation compared to cones in the peripheral retina. We find that this difference in adaptive properties between foveal and peripheral cones is due to differences in the magnitude of a hyperpolarization-activated current, I_h. This I_h current regulates the strength and time course of luminance adaptation in peripheral cones where it is more prominent than in

SUBMITTER: Saha A 

PROVIDER: S-EPMC11470117 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature