Structured testing of genetic association with mixed clinical outcomes.

ABSTRACT: Genetic factors play a fundamental role in disease development. Studying the genetic association with clinical outcomes is critical for understanding disease biology and devising novel treatment targets. However, the frequencies of genetic variations are often low, making it difficult to examine the variants one-by-one. Moreover, the clinical outcomes are complex, including patients' survival time and other binary or continuous outcomes such as recurrences and lymph node count, and how to effectively analyze genetic association with these outcomes remains unclear. In this article, we proposed a structured test statistic for testing genetic association with mixed types of survival, binary, and continuous outcomes. The structured testing incorporates known biological information of variants

SUBMITTER: Liu M 

PROVIDER: S-EPMC11470132 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature