Five multivariate Duchenne muscular dystrophy progression models bridging six-minute walk distance and MRI relaxometry of leg muscles.

ABSTRACT: The study aimed to provide quantitative information on the utilization of MRI transverse relaxation time constant (MRI-T₂) of leg muscles in DMD clinical trials by developing multivariate disease progression models of Duchenne muscular dystrophy (DMD) using 6-min walk distance (6MWD) and MRI-T₂. Clinical data were collected from the prospective and longitudinal ImagingNMD study. Disease progression models were developed by a nonlinear mixed-effect modeling approach. Univariate models of 6MWD and MRI-T₂ of five muscles were developed separately. Age at assessment was the time metric. Multivariate models were developed by estimating the correlation of 6MWD and MRI-T₂ model variables. Full model estimation approach for covariate analysis and five-fo

SUBMITTER: Yoon DY 

PROVIDER: S-EPMC11470134 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature