Tea intake and non-alcoholic fatty liver disease risk: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a major global health problem due to its great disease and economic burdens. Tea is a popular beverage consumed by billions of people.globally owing to its health benefits. However, the evidence regarding the association between tea intake and NAFLD risk is inconsistent.

Objective

To examine the genetically predicted causal association between tea intake and NAFLD risk using the two-sample Mendelian randomization (MR) method.

Methods

Single-nucleotide polymorphisms (SNPs) strongly associated with tea intake were obtained from a large dataset (N = 447,485) in the UK biobank, and summary-level genetic data for NAFLD (2,275 cases and 375,002 controls) were collected from the FinnGen consortium. The two-sample MR met

SUBMITTER: Lu C 

PROVIDER: S-EPMC11470174 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature