Resistance and resilience to tau pathology in Alzheimer's disease: Effects of age, sex, and <i>APOE</i> alleles.

ABSTRACT:

Introduction

Neurofibrillary tangles (NFTs), a hallmark of tau pathology in Alzheimer's disease (AD), accumulate in the aging brain. However, some individuals remain cognitively intact despite high Braak (III-VI) stages, which characterize NFTs' accumulation.

Methods

We studied resistance and resilience to tau pathology by assessing Braak stages based on apolipoprotein E (APOE) alleles, sex, and age in a sample of 1932 cognitively intact individuals of European ancestry from the Alzheimer's Disease Sequencing Project (ADSP).

Results

Resistance, characterized by low (0-II) Braak stages, was observed in men and women younger than 85 years of age. Resilience, indicated by high (III-VI) Braak stages, increased significantly with age in both men and women for each <

SUBMITTER: Loika Y 

PROVIDER: S-EPMC11470232 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature