Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population.

ABSTRACT: Atopic dermatitis (AD) is a chronic itchy inflammatory disease of the skin. Genetic studies have identified multiple risk factors linked to the disease; however, most of the studies have been derived from European and East Asian populations. The admixed African American (AA) genome may provide an opportunity to discovery ancestry-specific loci involved in AD susceptibility. Herein, we present joint analysis of ancestry and genotype effects followed by validation using differential gene expression analysis on AD using 726 AD-affected individuals and 999 non-AD control individuals from the AA population, genotyped using Multi-Ethnic Global Array (MEGA) followed by imputation using the Consortium on Asthma among African Ancestry Populations in the Americas (CAAPA) reference panel. The joint a

SUBMITTER: Gautam Y 

PROVIDER: S-EPMC11470243 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature