The mitochondrial Na⁺/Ca²⁺ exchanger NCLX is implied in the activation of hypoxia-inducible factors.

ABSTRACT: Eukaryotic cells and organisms depend on oxygen for basic living functions, and they display a panoply of adaptations to situations in which oxygen availability is diminished (hypoxia). A number of these responses in animals are mediated by changes in gene expression programs directed by hypoxia-inducible factors (HIFs), whose main mechanism of stabilization and functional activation in response to decreased cytosolic oxygen concentration was elucidated two decades ago. Human acute responses to hypoxia have been known for decades, although their precise molecular mechanism for oxygen sensing is not fully understood. It is already known that a redox component, linked with reactive oxygen species (ROS) production of mitochondrial origin, is implied in these responses. We have recently descri

SUBMITTER: Choya-Foces C 

PROVIDER: S-EPMC11470253 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature