Complete absence of GLUT1 does not impair human terminal erythroid differentiation.

ABSTRACT:

Abstract

The glucose transporter 1 (GLUT1) is 1 of the most abundant proteins within the erythrocyte membrane and is required for glucose and dehydroascorbic acid (vitamin C precursor) transport. It is widely recognized as a key protein for red cell structure, function, and metabolism. Previous reports highlighted the importance of GLUT1 activity within these uniquely glycolysis-dependent cells, in particular for increasing antioxidant capacity needed to avoid irreversible damage from oxidative stress in humans. However, studies of glucose transporter roles in erythroid cells are complicated by species-specific differences between humans and mice. Here, using CRISPR-mediated gene editing of immortalized erythroblasts and adult CD34+ hematopoietic progenitor cells, we generate commi

SUBMITTER: Martins Freire C 

PROVIDER: S-EPMC11470287 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature