Jiannao pills mitigate chronic restraint stress-induced anxiety in mice through the regulation of intestinal microflora.

ABSTRACT:

Objective

To investigate the effects of Jiannao pills on mice with chronic restraint stress-induced anxiety and its mechanisms.

Methods

Anxiety-like behaviors were induced in mice by exposing them to chronic restraint stress (8 h/day for 21 days). Subsequently, Jiannao pills were given to these mice for the treatment of the induced anxiety. Following treatment, the intestinal microflora of the mice were analyzed using the 16S rRNA sequencing method.

Results

Under positive electrospray ionization mode, a total of 68 chemical compositions were found in Jiannao pills, and under negative electrospray ionization mode, the number was 18. With these chemical compositions in effect, it was observed that Jiannao pills alleviated chronic restraint induced anxiety-like behaviors

SUBMITTER: Pan J 

PROVIDER: S-EPMC11470306 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature