Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits.

ABSTRACT:

Objective

Intestinal gluconeogenesis (IGN) regulates adult energy homeostasis in part by controlling the same hypothalamic targets as leptin. In neonates, leptin exhibits a neonatal surge controlling axonal outgrowth between the different hypothalamic nuclei involved in feeding circuits and autonomic innervation of peripheral tissues involved in energy and glucose homeostasis. Interestingly, IGN is induced during this specific time-window. We hypothesized that the neonatal pic of IGN also regulates the development of hypothalamic feeding circuits and sympathetic innervation of adipose tissues.

Methods

We genetically induced neonatal IGN by overexpressing G6pc1 the catalytic subunit of glucose-6-phosphatase (the mandatory enzyme of IGN) at birth or at twelve days after birth.

SUBMITTER: Estrada-Meza J 

PROVIDER: S-EPMC11470480 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature