Potential immunologic and prognostic roles of CHRNA6 in SCLC and pan-cancer.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is considered the most malignant subtype of lung cancer, and it has a restricted range of therapeutic choices. The emergence of immunotherapy has offered new possibilities for patients with SCLC. However, the scarcity of clinical specimens has hampered the progress of clinical studies and we still face a shortage of dependable indicators to forecast the effectiveness of immunotherapy for SCLC.

Methods

In our study, we assessed the ImmuneScore and StromalScore of 81 SCLC samples obtained from the cBioPortal database. By comparing gene expression differences between the high and low immune scores groups, we identified 24 differentially expressed genes. Subsequently, an intersection was performed with genes that exhibited differential ex

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11470509 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature