Time-course analysis of antibody and cytokine response after the third SARS-CoV-2 vaccine dose.

ABSTRACT: The widespread administration of an additional dose of the SARS-CoV-2 vaccine has been promoted across adult populations, demonstrating a robust immune response against COVID-19. Longitudinal studies provide crucial data on the durability of immune response after the third vaccination. This study aims to explore the antibody response, neutralizing activity, and cytokine response against the SARS-CoV-2 ancestral strain (wild-type) and its variants during the timeline before and after the administration of the third vaccine dose. Anti-spike antibody titers and neutralizing antibodies blocking ACE2 binding to spike antigens were measured in 62 study participants at baseline, and on days 7, 21, and 180 post-vaccination. Cytokine levels were assessed at the same points except for day 180, with

SUBMITTER: Kim HH 

PROVIDER: S-EPMC11470517 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature