An outbreak of bla_KPC-4- and bla_VIM-1-producing Klebsiella pneumoniae and Klebsiella variicola at a single hospital in South Korea.

ABSTRACT:

Background

The dissemination of Klebsiella spp. producing multiple carbapenemases has been increasingly recognized. Between July 2019 and August 2021, ten patients were found to carry Klebsiella spp. co-harboring bla_KPC-4 and bla_VIM-1 across multiple wards at a Korean hospital, and one isolate was recovered from a hand-washing sink, more than a year after the outbreak. This study aimed to investigate the outbreak and conduct a genomic study of these isolates.

Methods

Whole-genome sequencing, including long-read sequencing, was performed to analyze plasmid structures and mobile genetic elements (MGEs). Bioinformatics analyses were performed to trace clonal transmission chains and horizontal gene transfer.

Results

The findings suggested that the in

SUBMITTER: Chu J 

PROVIDER: S-EPMC11470574 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature