Identification of cuproptosis-related genes in Alzheimer's disease based on bioinformatic analysis.

ABSTRACT:

Objective

To explore the role of cuproptosis in Alzheimer's disease (AD).

Methods

An AD-related microarray dataset was downloaded from the Gene Expression Omnibus (GEO) database (GSE140830). Weighted gene co-expression network analysis was used to identify AD-related modular genes. The Venn analysis was performed to obtain module genes associated with apoptosis and cuproptosis. Besides, we conducted an enrichment analysis of overlapped genes and constructed the protein-protein interaction (PPI) network, followed by screening hub genes and those significantly associated with AD were used to construct models of apoptosis and cuproptosis, respectively. Further, receiver operating characteristic (ROC) curve analysis, decision curve analysis (DCA), and subgroup analysis were used

SUBMITTER: Ma MM 

PROVIDER: S-EPMC11470641 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature