Harm effects in non-registered versus registered randomized controlled trials of medications: a retrospective cohort study of clinical trials.

ABSTRACT:

Background

Trial registration aims to address potential bias from selective or non-reporting of findings, and therefore has a vital role in promoting transparency and accountability of clinical research. In this study, we aim to investigate the influence of trial registration on estimated harm effects in randomized controlled trials of medication interventions.

Methods

We searched PubMed for systematic reviews and meta-analyses of randomized trials on medication harms indexed between January 1, 2015, and January 1, 2020. To be included in the analyses, eligible meta-analyses should have at least five randomized trials with distinct registration statuses (i.e., prospectively registered, retrospectively registered, and non-registered) and 2 by 2 table data for adverse events f

SUBMITTER: Xu C 

PROVIDER: S-EPMC11470660 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature