Transcriptome-wide N6-methyladenosine modification profiling of long non-coding RNAs in patients with recurrent implantation failure.

ABSTRACT: N⁶-methyladenosine (m⁶A) is involved in most biological processes and actively participates in the regulation of reproduction. According to recent research, long non-coding RNAs (lncRNAs) and their m⁶A modifications are involved in reproductive diseases. In the present study, using m⁶A-modified RNA immunoprecipitation sequencing (m⁶A-seq), we established the m⁶A methylation transcription profiles in patients with recurrent implantation failure (RIF) for the first time. There were 1443 significantly upregulated m⁶A peaks and 425 significantly downregulated m⁶A peaks in RIF. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that genes associated with differentially methyl

SUBMITTER: Wang T 

PROVIDER: S-EPMC11470675 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature