Iron chelating, antioxidant, and anti-inflammatory properties of brazilin from Caesalpinia sappan Linn.

ABSTRACT:

Background

Iron overload and inflammation are severe conditions that can lead to various chronic diseases. However, the current iron chelator drugs have their limitations. The phytochemical compounds from herbals, such as brazilin, the major active compound in Caesalpinia sappan Linn., have significant therapeutic potential in various chronic diseases. Our study was designed to examine the effect of brazilin on iron chelating properties, antioxidant activity in hepatocytes, and anti-inflammatory potential in macrophages.

Methods

This study focused on the isolation, purification, and evaluation of brazilin, the principal bioactive constituent found in C. sappan wood. Brazilin was extracted via methanol maceration followed by column chromatography purifica

SUBMITTER: Taveepanich S 

PROVIDER: S-EPMC11470788 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature