Influence of intergenerational social mobility on brain structure and global cognition: findings from the Whitehall II study across 20 years.

ABSTRACT:

Background

Whether changes in socioeconomic position (SEP) across generations, i.e. intergenerational social mobility, influence brain degeneration and cognition in later life is unclear.

Objective

To examine the association of social mobility, brain grey matter structure and global cognition.

Methods

We analysed T1 brain MRI data of 771 old adults (69.8 ± 5.2 years) from the Whitehall II MRI substudy, with MRI data collected between 2012 and 2016. Social mobility was defined by SEP changes from their fathers' generation to mid-life status. Brain structural outcomes include grey matter (GM) volume and cortical thickness (CT) covering whole brain. Global cognition was measured by the Mini Mental State Examination. We firstly conducted analysis of covariance to identify

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11470806 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature