A Network and Pathway Analysis of Genes Associated With Atrial Fibrillation.

ABSTRACT: Background: Atrial fibrillation (AF) is affected by both environmental and genetic factors. Previous genetic association studies, especially genome-wide association studies, revealed a large group of AF-associated genes. However, little is known about the functions and interactions of these genes. Moreover, established genetic variants of AF contribute modestly to AF variance, implying that numerous additional AF-associated genetic variations need to be identified. Hence, a systematic network and pathway analysis is needed. Methods: We retrieved all AF-associated genes from genetic association studies in various databases and performed integrative analyses including pathway enrichment analysis, pathway crosstalk analysis, network analysis, and microarray meta-analysis. Res

SUBMITTER: Zeng M 

PROVIDER: S-EPMC11470814 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature