Regulation of pro-apoptotic and anti-apoptotic factors in obesity-related esophageal adenocarcinoma.

ABSTRACT:

Background

Obesity is a risk factor for esophageal adenocarcinoma (EAC). It was reported that obesity -associated inflammation correlates with insulin resistance and increased risk of EAC. The objective of the study is to investigate the role of obesity associated inflammatory mediators in the development of EAC.

Methods

We included 23 obese and nonobese patients with EAC or with or without Barrett's esophagus (BE) after IRB approval. We collected 23 normal, 10 BE, and 19 EAC tissue samples from endoscopy or esophagectomy. The samples were analyzed for the expression levels of pro-apoptotic and anti-apoptotic factors, PKC-δ, cIAP2, FLIP, IGF-1, Akt, NF-kB and Ki67 by immunofluorescence and RT-PCR. We compared the expression levels between normal, BE, and EAC tissue using Stu

SUBMITTER: Agrawal S 

PROVIDER: S-EPMC11470870 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature