Association between brain resting-state functional activities and migraine: a bidirectional mendelian randomization study.

ABSTRACT: Researchers have conducted extensive research on the correlation between brain resting-state functional activities (RSFA) and migraine. However, we still do not fully understand the exact nature of the causal relationship between these RSFA and migraine. We conducted a bidirectional two-sample Mendelian randomization (MR) study to investigate the causal association between migraine and RSFA. We gathered summary statistics from genome-wide association studies for 191 resting-state functional magnetic resonance imaging phenotypes. We employed various analytical methods for bidirectional two-sample MR analyses. This included inverse variance weighted, weighted median, MR Egger, and the constrained maximum likelihood approaches. We also conducted pleiotropy and heterogeneity analyses to evalua

SUBMITTER: Lu Q 

PROVIDER: S-EPMC11470954 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature