Spatial multiomics atlas reveals smooth muscle phenotypic transformation and metabolic reprogramming in diabetic macroangiopathy.

ABSTRACT:

Background

Diabetic macroangiopathy has been the main cause of death and disability in diabetic patients. The mechanisms underlying smooth muscle cell transformation and metabolic reprogramming other than abnormal glucose and lipid metabolism remain to be further explored.

Method

Single-cell transcriptome, spatial transcriptome and spatial metabolome sequencing were performed on anterior tibial artery from 11 diabetic patients with amputation. Multi-omics integration, cell communication analysis, time series analysis, network analysis, enrichment analysis, and gene expression analysis were performed to elucidate the potential molecular features.

Result

We constructed a spatial multiomics map of diabetic blood vessels based on multiomics integration, indicating single-

SUBMITTER: Qian Y 

PROVIDER: S-EPMC11471023 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature