PHACTR1 and APOC1 genetic variants are associated with multi-vessel coronary artery disease.

ABSTRACT:

Background

Severe coronary artery disease (CAD) represents an advanced arterial narrowing, often associated with critical complications like myocardial infarction and angina. This study aimed to comprehensively investigate determinants of severe and multi-vessel CAD manifestations.

Methods

One thousand nine hundred patients with severe and multivessel CAD (stenosis > 70%) were recruited along with 1,056 controls without stenosis. Associations using a genotyping panel comprising 159 Single Nucleotide Polymorphisms (SNPs) previously implicated in CAD pathogenesis were examined and these associations were replicated using the UK Biobank cohort (N = 29,970).

Results

The investigation identified 14 genetic associations with severe CAD, of which 7 were also associated with

SUBMITTER: Al Hageh C 

PROVIDER: S-EPMC11471027 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature