Comprehensive analysis of multiple regulated cell death risk signatures in lung adenocarcinoma.

ABSTRACT:

Background

Regulated cell death (RCD) has considerable impact on tumor progress and sensitivity of treatment. Lung adenocarcinoma (LUAD) show a high resistance for conventional radiotherapies and chemotherapies. Currently, regulation of cancer cell death has been emerging as a new promising therapeutic avenue for LUAD patients. However, the crosstalk in each pattern RCD is unclear.

Methods

We integrated collected the hub-genes of 12 RCD subroutines and compressively analyzed these hub-genes synergistic effect in LUAD. The characters of RCD genes expression and prognosis were developed in The Cancer Genome Atlas (TCGA)-LUAD data. We developed and validated an RCD risk model based on TCGA and GSE70294 data set, respectively. Functional annotation and tumor immunotherapy based

SUBMITTER: Gao S 

PROVIDER: S-EPMC11471212 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature