Differential involvement of central and peripheral catecholamines between Alzheimer's disease and vascular dementia.

ABSTRACT:

Background and aim

The important role of catecholamines has been gradually emphasized in the pathogenesis of neurodegenerative process. As the most prevalent form of cognitive dysfunction, Alzheimer's disease (AD) and vascular dementia (VaD) have the distinct pathological features and pathogenic mechanisms, however, the differential involvement of central and peripheral catecholamines between AD and VaD was still unclear.

Methods

Triple-transgenic AD (3 × Tg-AD) mice and chronic cerebral hypoperfusion (CCH) in rats induced by two-vessel occlusion (2VO) were used as the AD and VaD model in this study, respectively. The concentrations of catecholamines (dopamine, epinephrine and norepinephrine) and their metabolites (3-methoxytyramine, metanephrine and normetanephrine) in seru

SUBMITTER: Hong XY 

PROVIDER: S-EPMC11471233 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature