Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.

ABSTRACT:

Objective

Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behaviors and metabolism.

Methods

We performed a detailed behavioural and metabolic analysis in mice lacking GHSRs in the OB (OB^GHSR deletion). We also analsyed OB scRNA-seq and spatial transcriptomic datasets to assess GHSR+ cells in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus.

Results

OB^GHSR deletion affected olfactory discrimination and habituation to both food and non-food odors. Anxiety-like and depression-like behav

SUBMITTER: Stark R 

PROVIDER: S-EPMC11471258 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature