VCAb: a web-tool for structure-guided exploration of antibodies.

ABSTRACT:

Motivation

Effective responses against immune challenges require antibodies of different isotypes performing specific effector functions. Structural information on these isotypes is essential to engineer antibodies with desired physico-chemical features of their antigen-binding properties, and optimal developability as potential therapeutics. In silico mutational scanning profiles on antibody structures would further pinpoint candidate mutations for enhancing antibody stability and function. Current antibody structure databases lack consistent annotations of isotypes and structural coverage of 3D antibody structures, as well as computed deep mutation profiles.

Results

The V and C region bearing antibody (VCAb) web-tool is established to cla

SUBMITTER: Guo D 

PROVIDER: S-EPMC11471263 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature